Peptic Ulcers

person experiencing stomach pain in a doctor's office setting

Understanding Peptic Ulcer Disease: A Gastroenterologist’s Perspective

Hello everyone,

I’m Dr. Krishna Rayapudi, a Gastroenterologist dedicated to helping my patients manage their digestive health. Today, I want to discuss peptic ulcer disease, its symptoms, causes, diagnosis, and treatment options.

What is Peptic Ulcer Disease?

Peptic ulcer disease (PUD) is a condition where open sores, or ulcers, develop on the inside lining of your stomach (gastric ulcers) or the upper part of your small intestine (duodenal ulcers). These ulcers occur when the stomach acid damages the lining of the digestive tract. The most common causes are infection with the bacterium Helicobacter pylori and long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprofen​​​​.

Symptoms of Peptic Ulcer Disease

The symptoms of PUD can vary depending on the ulcer's location and severity. Common symptoms include:


While some peptic ulcers may be asymptomatic, they can lead to serious complications if left untreated, such as:

Diagnosing Peptic Ulcer Disease

Diagnosis of PUD typically involves:

Treatment and Management

  1. Medications:

    • Antibiotics: If H. pylori is present, antibiotics are used to eradicate the infection.
    • Proton Pump Inhibitors (PPIs): Medications like omeprazole reduce stomach acid production, promoting healing.
    • Antacids and H2-Receptor Antagonists: These can help neutralize stomach acid and reduce pain.
  2. Lifestyle Changes:

    • Avoid NSAIDs: Substitute with other pain relievers if possible.
    • Dietary Adjustments: Avoid spicy foods, caffeine, and alcohol which can exacerbate symptoms.
    • Smoking Cessation: Smoking increases stomach acid and slows healing.
  3. Surgical Intervention: In rare cases where medication and lifestyle changes are ineffective, or complications arise, surgery may be necessary to remove the ulcer or reduce stomach acid production.

Our Approach

At our practice, we offer comprehensive care for patients with peptic ulcer disease. Our approach includes thorough diagnostic evaluations, tailored treatment plans, and ongoing support to ensure effective management and prevention of recurrence. We focus on patient education and lifestyle modifications to promote long-term health and well-being.


Peptic ulcer disease can significantly impact your quality of life, but with the right treatment and management strategies, it is possible to achieve relief and prevent complications. If you suspect you have an ulcer or are experiencing symptoms, please contact our office. We are here to help you every step of the way.

Stay healthy, Dr. Krishna Rayapudi MD DABOM

Krishna Rayapudi MD DABOM Krishna Rayapudi MD DABOM is board certified in Gastroenterology and Obesity Medicine. Trained in world-class facilities with world-class mentors. Managed thousands of patients in all practice setups possible, with experience in seven different US states. You learn more about his practice at

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